Pharmacodynamic Mechanism Study Based on 3Dmicroflu™

CD BioSciences is a cutting-edge biotechnology company committed to providing 3D bioprinted tissue and organ micro-models. With a team of experienced experts and a unique 3D printing technology platform called 3Dmicroflu™, we can provide you with relevant research services covering various life science fields. One of the very important applications of 3Dmicroflu™ technology platform for printing tissue and organ micro-models is drug development, for which pharmacodynamic studies are a very important part.

Overview of pharmacodynamics

Pharmacodynamics focuses on the study of the action of drugs on the organism and its pattern, which clarifies the mechanism of drug prevention and treatment of diseases. The main difference between pharmacokinetics and pharmacodynamics is that pharmacokinetics focuses on the action of the body on the drug, while pharmacodynamics focuses on the action of the drug on the body. They are different in nature but complement each other. When the drug is used to treat a disease, it also produces a series of untoward reaction or adverse reaction, including side effect, toxic reaction, allergy reaction, secondary reaction, aftereffects, discontinuation reaction, etc. These are the aspects of pharmacokinetics that need to be studied in the process of drug development.

• Side effects - Discomfort reactions that occur when the drug is used to treat a disease and are not related to the purpose of the treatment.
• Toxic reactions - Reactions that occur when the drug is overdosed or accumulated in the body,which are divided into acute toxic reactions and chronic toxic reactions.
• Allergic reactions - Abnormal immune reactions that occur when the body is stimulated by drugs, which can cause physiological dysfunction or tissue damage, also known as allergic reactions.
• Secondary reactions - Adverse consequences caused by the therapeutic effects of the drug.
• Aftereffects - Pharmacological effects that remain after the blood concentration has fallen below the minimum effective concentration after the drug has been discontinued.
• Discontinuation reactions - After long-term use of certain drugs, sudden discontinuation of the drug may aggravate the existing disease.

3Dmicroflu™ in the construction of pharmacodynamic research micro models

Pharmacokinetic studies are an important part of the drug development process, which are of great significance in formulating drug delivery regimens, determining the dose of drugs to be administered, guiding rational drug use and improving drug dosage forms. Here, the experienced team of experts from CD BioSciences can provide you with in vitro microtissue and organ models for your pharmacokinetic studies based on high-resolution 3Dmicroflu™ platform printing. As shown in the figure below, there are three main areas of application of 3Dmicroflu™ technology platform for pharmacokinetic studies, including drug toxicity study, drug tolerance analysis and drug safety evaluation.

Fig. 1. 3Dmicroflu™ technology platform is involved in the construction of micro-organ models for pharmacodynamic studies.

Most of the commonly used preclinical pharmacokinetic analysis models are animal models, which are likely to have different effects in humans, thus making the drug development process very long. Both pharmacokinetic and pharmacodynamic studies are used in drug development to determine whether drugs have clinical applications, so it makes more sense to use 3D printed biological models, and pharmacokinetic study models that fully reflect the actual physiological characteristics and environment can greatly facilitate the drug development process. Therefore, choosing 3Dmicroflu™ technology platform for your pharmacokinetic analysis will be of great help to your project.

If you are interested in 3Dmicroflu™-based pharmacodynamic research micro models, please feel free to contact us for customization services. All services are available on a 24/7/365 basis.