CD BioSciences has been a trusted biotechnology company and our services in bio-3D printing have been well-received by our customers. The team of experts from CD BioSciences provides various types of in vitro model construction services based on the high-resolution 3Dmicroflu™ technology platform, covering almost all aspects of life science research. Here, the advantages and applications of the 3Dmicroflu™ technology platform for building complex melanoma models in dermatological disease models are demonstrated below.
Melanoma is a highly malignant tumor of melanocytic origin that occurs mostly in the skin, but can also be seen in the mucous membranes and internal organs. DNA damage occurs in melanocytes as the basic cause of malignant melanoma. On the basis of genetic background, long-term ultraviolet radiation, repeated friction and traumatic stimulation lead to DNA breakage, translocation, mutation or abnormal methylation of melanocytes. Eventually melanocytes develop uncontrolled proliferation and abnormal differentiation, thus developing into malignant tumor cells.
According to the characteristics of pathogenesis, origin, disease course and prognosis, malignant melanoma is divided into two major categories, including in situ malignant melanoma and aggressive malignant melanoma.
Tumor cells are confined to the epithelial layer of epidermis or mucosa. In situ malignant melanoma mainly includes malignant freckle-like nevus, superficial diffuse in situ malignant melanoma, and limb in situ melanoma.
Tumor cells have broken through the basal layer of epidermis or mucosal epithelium and infiltrated into the dermis and deeper layers. Aggressive malignant melanoma mainly includes malignant freckle-like melanoma, superficial spreading malignant melanoma, limbic melanoma and nodular melanoma.
In vitro validation models have been an important component in the study of melanogenesis and related drug screening processes. If 3D printed melanoma models can be used instead of the commonly used mouse models, this will greatly advance the melanoma research process. At CD BioSciences, we can assist your experimental project through a technology platform called 3Dmicroflu™ by providing melanoma 3D printing services.
As mentioned above, it makes sense to build in vitro melanoma micro-models to replace animal models. Here, at CD BioSciences, we offer you a high-resolution 3Dmicroflu™ 3D printing technology platform that can be applied to the in vitro construction of melanoma models. The tumor model construction service from 3Dmicroflu™ technology platform has always been recognized and welcomed by our customers because of the greater accuracy and detail of single cell printing at high resolution. Single-cell 3D printing allows for the construction of precise and complex structures, such as melanoma models including solid tumors and the surrounding physiological environment. Melanoma micro-models from the technology platform can more realistically reflect the characteristics of the disease under physiological conditions.
Fig. 2. In vitro models built on 3Dmicroflu™ technology platform for melanoma mechanism research and drug screening.
By choosing our technology platform to carry out your experimental projects, you will get the following advantages.
If you are interested in 3Dmicroflu™-based vascular models or have a need for custom melanoma models of your experimental projects, please feel free to contact us for customization services. All services are available on a 24/7/365 basis.