CD BioSciences is a cutting-edge biotechnology company committed to providing 3D bioprinted tissue and organ micro-models. With a team of experienced experts and a unique 3D printing technology platform called 3Dmicroflu™, we can provide you with relevant research services covering various life science fields. One of the very important applications of 3Dmicroflu™ technology platform for printing tissue and organ micro-models is drug development, for which pharmacokinetic studies are a very important part. In the process of pharmacokinetic analysis, drug tolerance analysis is also an important aspect, which can provide effective help for rational drug use.
In pharmacology, drug tolerance is an adaptive state and result of the body's response to a drug. When a drug is used repeatedly, the organism's responsiveness to the drug diminishes and a decrease in efficacy occurs. In order to achieve the same response and efficacy as the original, it is necessary to gradually increase the dose of the drug. Because the body is tolerant to the drug, it is often necessary to stack and increment the dose to maintain the effect of the drug. Tolerance is essentially a decrease in the affinity of the receptor for the drug, which can include a decrease in the number of receptors, structural changes, site occupancy, etc. Both antibiotics and general therapeutic drugs follow this pattern. In general, drugs that cause a positive phenomenon result in down-regulation of receptors, while inhibitors result in up-regulation of receptors. This is a normal phenomenon. Drug tolerability varies between individuals, and better tolerated drugs have better potential for applications. Drug tolerance evaluation is one of the important data to be analyzed during the drug development phase and is one of the important bases for drug pre-screening. Therefore, drug tolerance analysis has significance and guidance in the drug development stage.
Tolerability analysis of drugs is very necessary and is an important reference for the screening process of potential drugs. Because if the drug is not well tolerated, it will not only affect the dosage of the drug, but also further affect the safety evaluation of the drug. The organism is not sensitive to the drug often need to improve the drug dosage and frequency of use to drug effectiveness. This can increase the detoxification burden on healthy organs and tissues of the body. Here, our high-resolution 3Dmicroflu™ technology platform can provide you with high-resolution 3D bioprinting services to print in vitro micro-models of disease and healthy tissues for drug tolerance analysis, which can help you determine the different effects of drug dosage on diseased and normal tissues. The ultimate goal of drug tolerance analysis is to determine the minimum drug dosage to achieve the target efficacy and the maximum drug dosage without damaging normal tissues. The results of drug tolerance assessment are useful for drug safety evaluation and subsequent dosing regimen design. 3Dmicroflu™ technology platform can ensure the accuracy of your tolerance analysis data by providing in vitro model construction services that fully reflect the physiological state of the drug. This is not a concern for you.
Fig. 1. The process of 3Dmicroflu™ technology platform involved in drug tolerance analysis.
Using 3Dmicroflu™ technology platform from CD BioSciences to build the drug tolerance analysis models you need, you can implement the following applications.
In the process of drug development, the following projects can be realized regarding the tolerance analysis of drugs through 3Dmicroflu™ technology platform.
If you are interested in 3Dmicroflu™ technology platform involved in drug tolerance analysis during drug development, please feel free to contact us for customization services. We always hope that our technology platform will be of great help and provide guidance to your R&D process. All services from CD BioSciences are available on a 24/7/365 basis.